Infectious Exposures And Hairy Cell Leukemia

The contribution of infectious pathogens to the etiology of cancer is being investigated for a multitude of cancers. Because of the association of Non-Hodgkin's lymphoma with Epstein-Barr virus (EB), Nordstrom reported on the correlation of exposure to Epstein-Barr virus and exposure to organochlorines as risk factors for HCL. High titres of antibodies to EB early antigen IgG, along with higher blood concentrations of chlor-danes, and hexachlorobenzene were correlated with an increased risk for HCL.16

A population-based case control study performed in Sweden through a mailed questionnaire to investigate the possible role of previous medical history and medications as risk factors for HCL was conducted by Nordstrom et al. Elevated odds ratio was found in those with a history of appendicitis and pneumonia, NSAID use, as well as a history of malignancy.17 There was no association found between cigarette smoking, alcohol, or coffee consumption and HCL.1115

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