5 year PFS: 38.9%

5 year(cause-specific): 46.5%

IFRT post-ASCT converted PR to CR in 10/10

Lancet et al. 70 0 27 5 year EFS: 44% vs 5 year: 81%

Lancet et al. 70 0 27 5 year EFS: 44% vs 5 year: 81%

involvement. Of 13 patients receiving IFRT after ASCT, 10 were treated at sites of persistent disease and three for CR consolidation. IFRT significantly reduced the relapse at these sites (26.3% vs 42.8%, P < 0.05) and significantly improved local control. Most importantly, all 10 patients who received IFRT at sites of persistent disease, as defined by CT criteria, were converted to a CR and had improved FFTF (40% vs 12.1%, P = 0.04) that was comparable to patients achieving CR with ASCT alone (40% vs 60.0%, P = 0.38).42

Lancet et al. described the experience at the University of Rochester with 27 of 70 patients who underwent ASCT receiving IFRT. Patients in CR, as defined by CT criteria, received 20 Gy to previous sites of disease while those achieving a PR posttransplant received 30 Gy within 4-8 weeks of ASCT. Five-year FFTF was significantly better in the consolidative IFRT group (44% vs 26%, P = 0.006). Consolidative RT has thus shown promise in its ability to convert some patients in PR, as defined by CT criteria, to CR with apparent long-term benefits.43

0 0

Post a comment