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Establish therapy duration

D (50 mg/m2/day X 2 days) + A (100 mg/m2/day X 7 days) T (100 mg/m2 q 12 h X 7 days) X 1 cycle vs

D (50 mg/m2/day X 2 days) + A (100 mg/m2/day X 7 days) + T (100 mg/m2 q 12 h X 7 days) X 1 cycle; D (50 mg/m2/day X 2 days) + A (100 mg/m2/day X 5 days) T (100 mg/m2 q 12 h X 5 days) X 1 cycle; C (600 mg/m2 X 1 day) + O (1.5 mg/m2 X 1 day) + A (100 mg/m2/day X 5 days + Pred (60 mg/m2 X 5 days) X 2 cycles

100%

Patients randomized to prolonged postremission therapy had a higher 5-year disease-free survival (23% vs 16% for the DAT arm) and lower relapse risk at 5 years (73% vs 81% for the DAT arm), but also more deaths in first complete remission (8% vs 3% in the DAT arm). Differences were not significant

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