Info

MALT, mucosa-associated lymphoid tissue; REAL, Revised European-American Classification of Lymphoid Neoplasms. Adapted from The Non-Hodgkin's Lymphoma Classification Project.75

MALT, mucosa-associated lymphoid tissue; REAL, Revised European-American Classification of Lymphoid Neoplasms. Adapted from The Non-Hodgkin's Lymphoma Classification Project.75

specified" category (PTCL, NOS), the number of transformed blast counts per 10 high-power fields was statistically significant for both overall and failure-free survival.2 Although the IPI project did not allow analysis of the influence of immunophenotype on overall survival results, investigators have used the IPI to predict outcome for T-cell lymphomas. For example, RĂ¼diger et al.2 demonstrated that IPI scores (0-2 features vs 3-5 features) separated T-cell lymphomas into groups with significantly different overall survival and failure-free survival rates. Gisselbrecht et al.22 reported that 45% of patients with T-cell lymphomas had three or more adverse prognostic factors when stratified by their IPI score compared with only 37% of those with B-cell lymphomas. Furthermore, these investigators could still separate patients with T-cell lymphomas into groups with significantly different survival rates, using the IPI system. Results for each IPI group were also significantly worse for those with T-cell tumors compared to those for patients with B-cell lymphomas who had the same IPI scores, respectively, particularly for those with IPI scores of 2 or more. Melnyk et al.23 found that response and survival rates for patients with T-cell lymphomas were better for those with low rather than high IPI scores. In addition, Lopez-Guillermo et al.76 reported that patients with PTCL and low plus low/intermediate IPI scores had significantly better survival rates than those with high plus intermediate/high-risk scores. In the study of Ansell et al.,77 the IPI strongly predicted survival results when all patients were included in the analysis, and when patients were separated into cohorts of 60 years and younger and older than 60 years, the age-adjusted IPI also significantly predicted outcome. While hepatic and bone marrow involvement were also significant prognostic factors by univariate analysis, only the IPI remained significant by multivariate analysis. IPI scores also predicted overall survival rates for patients with T-cell lymphomas in the study reported by Reiser et al.,78 as did elevated LDH, B-symptoms, and extranodal involvement; however, the presence of bulky disease (>7.5 cm), advanced-stage III/IV disease and bone marrow involvement did not. Armitage and Weisenburger79 separated patients with PTCL into groups according to IPI, and found differences in survival rates for those with IPI scores of 0 and 1 as compared to those with IPI scores of 2 or greater, although these differences were not statistically significant. IPI scores also did not predict outcomes for patients with anaplastic large T-cell lymphomas.79

0 0

Post a comment