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aThe frequency is approximately 25% for childhood precursor B-cell ALL.

aThe frequency is approximately 25% for childhood precursor B-cell ALL.

analyses. These diagnostic techniques allow for precise determination of specific ALL genotypes that provide important prognostic information. Molecular genetic alterations in ALL are given in Table 12.3. DNA microarray analysis may also provide unique gene expression profiles which will continue to refine the classification of ALL subtypes.45 46 Chapter 11 also specifically reviews the molecular biology of ALL. As FISH and RT-PCR are more sensitive techniques at detecting prognostically important cytogenetic abnormalities than is traditional karyotyping, we recommend use of one of these madalities to determine the presence of t(9;22) or t(4;11).

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