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IgA, immunoglobulin A; IgD, immunoglobulin D; IgG, immunoglobulin G; NR, not reported.

aOne case was biclonal (IgAX, IgEX).

From Ref. 41, with permission from Elsevier.

IgA, immunoglobulin A; IgD, immunoglobulin D; IgG, immunoglobulin G; NR, not reported.

aOne case was biclonal (IgAX, IgEX).

From Ref. 41, with permission from Elsevier.

The median age ranged between 53 and 57 years, which is a decade younger than that in a large recent myeloma cohort.42 Patients with primary PCL are younger and have a higher incidence of hepatosplenomegaly and lymphadenopathy, a higher platelet count, fewer lytic lesions, a lower serum M-protein level, and longer survival than do patients with secondary PCL.27 28 It is obvious from these series that primary PCL has a more aggressive clinical presentation than does multiple myeloma with a higher frequency of extramedullary involvement, anemia, thrombocytopenia, hypercal-cemia, and renal impairment. The presence of lytic bone lesions is lower than that observed in multiple myeloma.

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