Inhibitors Of Vegf Receptor

VEGF stimulates autocrine and paracrine growth of MM cells. VEGF achieves its action through its binding to three tyrosine kinase receptors—VEGF receptor 1(also called FMS-like tyrosine kinase receptor 1), VEGF receptor 2 (also called kinase insert domain containing receptor), and VEGF receptor 3 (also called FMS-like tyrosine kinase receptor 4).76 VEGF receptor 1 is the most commonly expressed VEGF in MM patients. In a phase II study, no objective response was seen in patients with refractory MM when treated with VEGF receptor 2 (SU5416).77 However, antiangiogenic properties of SU5416 can be used in combination with other agents in treating relapsed/refractory MM.

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