Interferon In Purine Analogresistant

Because interferon was used more often prior to the reported efficacy of purine analogs in HCL, there is only limited data on its efficacy in purine-resistant HCL. In 10 patients from the Intergroup study who crossed over from pentostatin to interferon, there were no responses. Interferon was effective in patients after failure of splenectomy and prior chemotherapy, but it was not clear, and perhaps unlikely, that any of these patients had received prior therapy with purine analogs.21 Nevertheless, interferon is a treatment recommended for relapsed HCL, particularly when cytopenias are severe and avoidance of myelotoxicity from purine analogs is a goal.22

0 0

Post a comment