Single-agent interferon alpha has been evaluated in a small series of patients with acute, lymphomatous, and chronic ATL, with OR rates of 25-33% and CR rates of 0-25%.79,80 There have been anecdotal reports using interferon beta and gamma to treat patients with ATL with modest activity.81 Twelve patients have been treated with interferon alpha in combination with bestrabucil, a conjugate of chlorambucil and p-estradiol, and prednisolone.82 Nine of the patients (75%) obtained a PR with a median response duration of 9 weeks.

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