Leukocyte Count At Presentation

The majority of clinical studies have identified a high presenting white blood cell (WBC) count as an adverse prognostic factor that influences both CR rate and duration.512-14 Despite intensification of recent regimens, lower remission durations in this subset of patients persist, particularly in those with precursor B ALL and WBC counts of higher than 100,000/^L.15 The same degree of hyperleukocytosis has not been as clearly associated with an adverse prognosis in precursor T ALL, in which patients routinely present with higher WBC counts.

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