Liver

Hepatic infiltration by HCs is a constant feature of HCL, but the organ is usually not markedly enlarged, and its general architecture remains intact. Both sinusoids and portal tracts are involved. In the sinusoids, the HCs may lie free within the lumen or be closely associated with the endothelium and adjacent hepato-cytes.6 In the portal tracts, the infiltrate is associated with marked fibrosis. This fibrosis is likely to involve the same mechanisms as described for BM.30

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