Lymph Nodes

Although clinical lymphadenopathy is uncommon in HCL, at postmortem some lymph node involvement is usually found. The infiltration is paracortical and at least some follicles are usually preserved.42 This relative sparing of lymph nodes may be the result of low or absent L-selectin (CD62L)7 and CCR7.4

In advanced disease, prominent upper abdominal lymphadenopathy may occur. The infiltrating HCs are larger and of more immature appearance than typical HCs, suggesting that such node enlargement is a consequence of disease transformation.45

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