Making The Diagnosis

Although the complete blood count and bone marrow findings in CML cases may be classic, less marked phe-notypic presentations may mimic other myeloprolifera-tive diseases, especially AMM. The diagnosis rests on the demonstration of the Ph chromosome in the bone marrow, the (9;22) translocation in the marrow or peripheral blood by FISH (fluorescent in situ hybridization) studies, or by reverse transcriptase analysis by polymerase chain reaction (RT-PCR) of the marrow or blood for the molecular abnormality, the BCR-ABL oncogene.

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