Marginal Zone Lymphoma Of Mucosaassociated Lymphoid Tissue

This type of lymphoma arises in extranodal sites and recapitulates the histology of the Peyer's patch.29 The stomach is the commonest site. MALT lymphomas are, by definition, low grade. Transformation to a diffuse large B-cell (high-grade) lymphoma can occur and this phenomenon is clinically significant and should be documented in the histology report. However, the term "high-grade MALT lymphoma" should not be used for these cases. In particular, DLBCLs arising de novo at extranodal sites where MALT lymphomas occur, such as the stomach, should not be called highgrade MALT lymphomas since this terminology may bias the clinician toward inappropriate therapy.

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