Mcsf

Receptor present

Stimulates chemokinesis and chemotaxis of HCs

bFGF

Both FGFR1 and CD44v3 co-receptor present

Involved in FN production by HA-adherent HCs.

May stimulate increased angiogenesis in HCL bone marrow

TGFß

Not studied

Elevated in HCL serum and BM. May be involved in suppression of the production and function of normal hematological cells, and stimulates BM fibroblasts to produce the collagen component of reticulin fibrosis

IFNa Receptor present Induces HC apoptosis in the absence of cell adhesion and may induce autocrine production of TNF

IFNa Receptor present Induces HC apoptosis in the absence of cell adhesion and may induce autocrine production of TNF

with a number of extracellular matrix (ECM) components including fibronectin (FN), vitronectin (VN), and hyaluronan (HA) (see Table 29.5). On FN, HCs firmly adhere and assume a spread morphology, whereas on VN and HA they display polarized morphology and pronounced motility.1421 This spectrum of behavior is likely to reflect both differences in the interaction of various adhesion receptors with the activated cortical cytoskeleton, as well as differences in signals generated by these receptors upon ligand binding. With regard to their interaction with FN, HCs are unique among B cells because of their ability to synthesize this protein and also to assemble it into matrix,22 in a process that requires FN binding to activated a5pi integrin.23 24

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