Mixed cellularity Hodgkins lymphoma

The mixed cellularity subtype is observed more frequently in patients with HIV disease, or in developing countries. It comprises 20-25% of classical HL cases, and is characterized by scattered Hodgkin's or Reed-Sternberg cells within a diffuse mixed inflammatory infiltrate without fibrosis.13 In contrast to NS HL, patients with MC HL are older (median age 37), predominantly male, and often with advanced-stage disease and B symptoms. Splenic involvement is reported in 30% of patients, bone marrow involvement in 10%, and liver involvement in 3%. Mediastinal presentations are uncommon.13

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