Molecular and immunohistochemical risk factors in DLBCL

Expression of many individual proteins detected by immunohistochemistry has been shown to have prognostic value in DLBCL. Examples of some of these are summarized in Table 66.4. The technique of GEP in which expression of thousands of genes can be investigated using cDNA or oligonucleotide probes has now been reported by several groups. The patterns of gene expression have been shown to correlate with clinical outcome and have led to the development of new prognostic models.

Table 66.3 Five year relapse free and overall survival rates according to the IPI and age-adjusted IPI

0 0

Post a comment