Molecular Cr

Molecular CR has been associated with clinical outcome in ALL12'24-40 (Table 14.2). However, the degree of sensitivity may have an impact on the correlation with clinical outcome. For example, Roberts and colleagues41 detected one abnormal cell in 105 or more normal cells, and concluded that their finding did not predict relapse because the test either detected preleukemic or nondi-viding cells. Detecting one abnormal cell in 104 or fewer

Table 14.2 Sensitivity of minimal residual disease detection by molecular analyses

Disease

Molecular target

Sensitivity

References

ALL (age >15 years old)

IgH

1-5:102-103

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