Molecular Genetic Analysis

Genetic alterations in ALL may be detected by cytoge-netic, fluorescent in situ hybridization (FISH), and reverse transcriptase polymerase chain reaction (RT-PCR)

Table 12.2 Immunophenotypes of ALL subtypes

Surface markers

B lineages

Early precursor B cell TdT+, CD19+, HLA-DR+, cCD79a+, cCD22 +

Precursor B cell TdT+, CD19+, HLA-DR+, CD10+, cIg +

T lineages

TdT, terminal deoxynucleotidyl transferase; c, cytoplasmic; s, surface;

Ig, immunoglobulin.

Table 12.3 Genotypes in adult and childhood ALL41-42-44

Cytogenetic

Genetic

Childhood

Adult

abnormality

alteration

frequency (%)

frequency (%)

t(9;22)

BCR/ABL

0 0

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