Molecular Genetics

Functional, clonal Ig rearrangements are generally present in the neoplastic cells. However, clonal rearrangements are rarely detected by PCR or Southern blot studies of intact tissue and have usually been identified only after single-cell microdissection.19 Characteristic recurrent cytogenetic abnormalities have not been described.

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24. Stein H, Mason DY, Gerdes J, et al.: The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that ReedSternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848-858, 1985.

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31. Bennett MH, MacLennan KA, Easterling MJ, Vaughan HB, Jelliffe AM, Vaughan HG: The prognostic significance of cellular subtypes in nodular sclerosing Hodgkin's disease: an analysis of 271 non-laparotomised cases (BNLI report no. 22). Clin Radiol 34:497-501, 1983.

32. Jarrett AF, Armstrong AA, Alexander E: Epidemiology of EBV and Hodgkin's lymphoma. Ann Oncol 7(suppl 4):5-10, 1996.

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35. Uccini S, Monardo F, Stoppacciaro A, et al.: High frequency of Epstein-Barr virus genome detection in

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36. Poppema S, Kaiserling E, Lennert K: Hodgkin's disease with lymphocytic predominance, nodular type (nodular paragranuloma) and progressively transformed germinal centres—a cytohistological study. Histopathology 3:295-308, 1979.

37. Ferry JA, Zukerberg LR, Harris NL: Florid progressive transformation of germinal centers. A syndrome affecting young men, without early progression to nodular lymphocyte predominance Hodgkin's disease. Am J Surg Pathol 16:252-258, 1992.

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43. Kamel OW, Gelb AB, Shibuya RB, Warnke RA: Leu 7 (CD57) reactivity distinguishes nodular lymphocyte predominance Hodgkin's disease from nodular scleros-ing Hodgkin's disease, T-cell-rich B-cell lymphoma and follicular lymphoma. Am J Pathol 142:541-546, 1993.

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Chapter 72

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10 Ways To Fight Off Cancer

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