Molecular Remission

Reverse transcriptase-polymerase chain reaction (RT-PCR) is the most sensitive method for detecting the bcr/abl transcript. A complete molecular remission means that the bcr/abl transcript cannot be detected by

Table 20.1 Definitions of remission in CML



5-Years survival with interferon

Hematologic Complete

Normal WBC and PLT Normal WBC differential No palpable splenomegaly No symptoms referable to CML



Decrease of WBC to <50% of the pretreatment level and

Normal WBC, but persistent splenomegaly or abnormal WBC differential

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