Mp

Melphalan Prednisone

8-9 mg/m2 PO, days 1-4 60 mg/m2 (or 100 mg) PO, days 1-4

q 28 days

M2 (VBMCP)31

Vincristine Carmustine (BCNU) Melphalan Cyclophosphamide Prednisone

0.03 mg/kg IVP, day 1 1 mg/kg IVPB, day 1 0.1 mg/kg PO, days 1-7 1 mg/kg IVPB, day 1 1 mg/kg PO, days 1-7

q 28 days

Melphalan

Cyclophosphamide

Prednisone

(alternating with)

Vincristine

Carmustine (BCNU)

Doxorubicin

Prednisone

1 mg IVP, day 1 5-6 mg/m2 PO, days 1-4 100-125 mg/m2 PO, days 1-4 60 mg/m2 PO, days 1-4

1 mg IVP, day 1 30 mg/m2 IVPB, day 1 30 mg/m2 IVP, day 1 60 mg/m2 PO, days 1-4

q 28 days

ABCM77

Doxorubicin Carmustine (BCNU) Cyclophosphamide Melphalan

30 mg/m2 IVP, day 1 30 mg/m2 IVPB, day 1 100 mg/m2 PO, days 22-25 6 mg/m2 PO, days 22-25

q 5-6 weeks

EDAP44

Etoposide Dexamethasone Cytarabine (Ara-C) Cisplatin

100 mg/m2/day, CIV, days 1-4 40 mg/day IV / PO, days 1-4 1 g/m2 IVPB, day 5 25 mg/m2/day, CIV, days 1-4

q 28 days

DCEP111'162

Dexamethasone Cyclophosphamide Etoposide Cisplatin

40 mg/day, IV / PO, days 1-4 400 mg/m2/day, CIV, days 1-4 40 mg/m2/day, CIV, days 1-4 10 mg/m2/day, CIV, days 1-4

q 28 days

MOCCA163

Methylprednisolone Vincristine Lomustine (CCNU) Cyclophosphamide Melphalan

0.8 mg/kg PO, days 1-7 0.03 mg/kg IVP, day 1 40 mg PO, day 1 10 mg/kg IVPB, day 1 0.25 mg/kg PO, days 1-4

q 35 days

explored,12 but there is insufficient data to support routine use at present,13 particularly in light of the recently recognized association between long-term bis-phosphonate use and the uncommon but potentially serious problem of osteonecrosis of the jaw (ONJ).14< 15

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