Multiple Solitary Plasmacytomas

The condition termed multiple solitary plasmacytomas is characterized by the simultaneous or sequential occurrence of discrete lesions in either bone or soft tissue (extramedullary). In contrast to multiple myeloma, the bone marrow is normal and radiography and magnetic resonance imaging show no evidence of diffuse skeletal involvement (Table 84.2). There is no end-organ damage other than the localized bone lesions. Multiple plasmacytomas may be treated with tumoricidal radiation, when recurrent, if there is no evidence of multiple myeloma. Large numbers of solitary plasmacytomas or recurrent lesions at short intervals are an indication for systemic therapy similar to that for multiple myeloma, such as autologous stem cell transplantation.

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