Myeloproliferative Symptoms

Increases in circulating mature (i.e., neutrophils) and immature (i.e., myelocytes, metamyelocytes, myeloblasts, etc.) myeloid cells occur in varying degrees in MMM. These cells have a propensity for accumulation in the reticuloendothelial system, particularly in the spleen and liver.8 These organs expand to accommodate the burden of myeloid cells, and the resulting hepatosplenomegaly may lead to pain, early satiety, sequestration of erythrocytes and platelets, and portal hypertension.9 Extramedullary hematopoiesis also can occur in the lungs (leading to pulmonary hypertension10), abdomen, spine,11 and pericardium.12

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