Nodular sclerosis Hodgkins lymphoma

The nodular sclerosis subtype accounts for 70% of classical HL.13 This subtype is morphologically characterized by collagen bands that surround Hodgkin's or Reed-Sternberg cells. NS HL equally affects males and females and the median age at diagnosis is 28 years. At diagnosis, most patients present with stage II disease, with mediastinal involvement noted in 80% of patients, bulky disease (see Diagnostic Evaluation section for definition of bulky disease) in 54%, and splenic or lung involvement in only 10%.4'13

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