Nr

N, number of patients enrolled; NR, not reported; ED, early death (death during induction); CR, complete response; EFS, event-free survival (any event, i.e., death or relapse, after enrollment on study); OS, overall survival; RR, relapse rate. a Results from the European APL Group.22 EFS, OS, and RR are reported at 4 years.

b Data are from the European APL Group20; EFS, OS, and RR are reported at 2 years. The high WBC count group received intensified induction and consolidation with ara-C.

c Results from the PETHEMA Group.58 Median follow up was 36 months; EFS, OS, and RR were reported at 6 years. d Results from the GIMEMA Group (AIDA93 and amended AIDA97 studies).59 OS was reported at 6 years. For ease of comparison, the EFS was estimated from the reported DFS (59%) and subtraction of the early death rate (12%). e Data are from the German AML Cooperative Group.25 EFS, OS, and RR reported at 4 years.

N, number of patients enrolled; NR, not reported; ED, early death (death during induction); CR, complete response; EFS, event-free survival (any event, i.e., death or relapse, after enrollment on study); OS, overall survival; RR, relapse rate. a Results from the European APL Group.22 EFS, OS, and RR are reported at 4 years.

b Data are from the European APL Group20; EFS, OS, and RR are reported at 2 years. The high WBC count group received intensified induction and consolidation with ara-C.

c Results from the PETHEMA Group.58 Median follow up was 36 months; EFS, OS, and RR were reported at 6 years. d Results from the GIMEMA Group (AIDA93 and amended AIDA97 studies).59 OS was reported at 6 years. For ease of comparison, the EFS was estimated from the reported DFS (59%) and subtraction of the early death rate (12%). e Data are from the German AML Cooperative Group.25 EFS, OS, and RR reported at 4 years.

high-risk features, mainly WBC count of more than 10,000/^L. Given that the disease biology is, if anything, more favorable in older adults, there is no reason to believe that, given proper treatment and supportive care, such individuals should not have a cure rate at least equal to younger adults.

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