Ns

difference

DFS - disease free survival; TRM - treatment related mortality; NS - not stated; OS - overall survival; MUD - matched unrelated donor transplant.

DFS - disease free survival; TRM - treatment related mortality; NS - not stated; OS - overall survival; MUD - matched unrelated donor transplant.

single center small retrospective analyses of heterogeneous groups of patients. The data from some studies addressing this issue are summarized in Table 42.1. The study by Copelan et al. suggests that the outcome in patients receiving induction therapy is in fact worse than those taken to transplant directly as a result of increased regimen related toxicity (RRT) compared to the group taken directly to a transplant.22 This issue needs to be further evaluated, especially in the setting of newer, less toxic remission induction agents, preferably as a prospective study. On the basis of the available data, it would be reasonable to take patients with a low percentage of bone marrow blasts directly to transplant, while patients with a bone marrow blast percentage closer to that of a diagnosis of acute myelo-cytic leukemia would probably benefit from induction therapy prior to a transplant. These recommendations must also be based on the age, motivations, and comorbidities of the patient.

0 0

Post a comment