Numerical Changes

Numerical changes are common in myeloma, occurring in 89-90% of cases using conventional and molecular cytogenetics.26 They are divided into "hypodipoid/pseudodiploid" and "hyperdiploid" changes. "Hypodiploidy" is associated with a poor prognosis, and the common ones are loss of chromosomes 8, 13, 14, and X, with the most prevalent one being monosomy 13. The common "hyperdiploidy" identified by both CC and FISH includes trisomies 1, 3, 5, 7, 9 , 11 ,15 ,19, and 21.21,58,59 Hyperdiploidy is associated with a good prognosis.

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