Oocyte Cryopreservation

Although successful fertilization and embryonic cleavage have been reported after injection of cryopreserved thawed oocytes, the pregnancy rate is not high enough to justify its routine use in clinical practice.54 The main reason for poor outcomes after oocyte cry-opreservation is related to the oocyte's structural complexity. Oocyte subcellular organelles are far more complex and perhaps more sensitive to thermal injury than preimplantation embryos. Oocyte donation may be considered in cases characterized by complete ovarian follicular depletion. However, the presence of other factors, such as uterine impairment, would be of major concern. In addition, complications during pregnancy and pre-term deliveries would be expected in these cases.55

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