Other Agents

Other agents that are under investigation for their role in the treatment of MM include those that act by interrupting intracellular signaling pathways, including the inhibitors of insulin-like growth factor 1 (IGF-1) receptor, inhibitors of the heat-shock protein 90, and the soluble RANKL antagonist, which decreases bone resorption. Inhibitors of lysophosphatidic acid acyl-transferase 3 (CT-32176, CT-32458, and CT-32615) in combination with HDAC inhibitors are under study for their role in MM treatment.76 Table 87.2 lists new agents now under study for treatment of relapsed or refractory MM.

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