Outcomes In The Era Of Haart

The CR rates for regimens using the combination of chemotherapy and HAART are 48-92% and the published 2-year overall survivals are 48-60%.46'47'53'58'71 These response rates and survival duration statistics are starting to approach those seen in the general population with advanced-stage high-grade lymphoma. Indeed, while the prognostic factors for survival in the pre-HAART era were predominantly immunologic (prior AIDS-defining illness and CD4 cell count),34 72 a more recent analysis of prognostic factors in AIDS-related lymphoma closely resembles that for the general population, with the International Prognostic

Index being an equally valuable guide in both circumstances.73'74

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