Overexpression Of The Baalc Gene

The BAALC gene, mapped to band 8q22.3, encodes a protein with no homology to any known proteins or functional domains. BAALC is expressed mainly in neu-roectoderm-derived tissues and hematopoietic precursors, with no expression in mature BM or blood mononuclear cells.65 High expression of BAALC mRNA in circulating blasts is an independent adverse prognostic factor in uniformly treated adults younger than 60 years with de novo AML and normal cytogenetics.1920 In another, smaller study, high expression of BAALC predicted shorter disease-free survival (DFS) and overall survival in patients with a normal karyotype who did not carry FLT3 ITD or mutations in the CEBPA gene.21

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