The diagnosis of a life-threatening disorder during pregnancy is a formidable challenge for both the patient and the physician. All risks, benefits, and alternatives for the patient and fetus must be discussed in detail. The patient should understand that no outcome can be guaranteed, but the available data should be presented to her in a comprehensive manner. Conclusions regarding the complexity of the decision to treat and continue the pregnancy should be reached by the consensus of the patient, patient's family, and physician. Unfortunately, there are no large prospective studies that address chemotherapy administration during pregnancy, and subsequently physicians are forced to formulate treatment regimens based on small retrospective studies and case reports.

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