Partial Hlamatched Related Donors

Partial HLA-matched related donors (PMRD) have been utilized as alternative donors for patients without an HLA-identical or phenotypically matched related donor.48-50,79-85 These cases nearly always involve a shared HLA haplotype between the patient and donor. The nature and number of mismatched HLA antigens or alleles can have an important effect on transplant outcome.

With partially matched related donors, the possibility of patient antibodies reactive with the mismatched HLA antigens should be addressed to avoid the associated risk of graft failure. Identification of patient antibodies against mismatched HLA antigens and a positive lymphocyte crossmatch against the donor strongly correlates with increased risk of graft failure.52,53,86

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