Pathology

Cases of LRCHL typically display a nodular growth pattern with some of the nodules containing germinal centers. There are scattered Reed-Sternberg cells and variants, usually within the mantle zones surrounding germinal centers (Figures 71.3 and 71.4). Some of the

Figure 71.3 Lymphocyte-rich classical Hodgkin's lymphoma. At low power, there is a lymphoid-rich infiltrate with a predominantly diffuse growth pattern. A residual germinal center is seen (center right)

Figure 71.4 Lymphocyte-rich classical Hodgkin's lymphoma. At high power, a binucleate Reed-Sternberg cell is present surrounded by numerous small lymphocytes

Figure 71.3 Lymphocyte-rich classical Hodgkin's lymphoma. At low power, there is a lymphoid-rich infiltrate with a predominantly diffuse growth pattern. A residual germinal center is seen (center right)

Figure 71.4 Lymphocyte-rich classical Hodgkin's lymphoma. At high power, a binucleate Reed-Sternberg cell is present surrounded by numerous small lymphocytes malignant cells may show multiple folded nuclear lobes ("popcorn cells"), reminiscent of those seen in nLPHL. There is no nodular sclerosis. Although rare scattered eosinophils and neutrophils may be present, they are not a prominent feature.

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