Phase Of Disease

The prior discussion refers to patients with chronic phase disease. Patients with accelerated or blastic phase disease have substantially worse outcomes with allogeneic transplantation. Approximately one in three patients with accelerated phase disease is cured by allogeneic transplantation.1-6 47 Higher rates of success have been reported in some studies; however, the use of different definitions of accelerated phase disease complicates interpretation of these data. Only one in ten patients with blastic phase disease is cured by transplantation.1-747

Figure 37.3 The probability of event-free survival for patients with chronic phase chronic myelogenous leukemia undergoing allogeneic transplantation less than 3 months, 3 months to a year, or more than a year
Figure 37.4 No deaths occurred beyond 12 years in any group. Among low-risk patients, 12 in the matched group and four in the mismatched group have follow-up beyond 12 years and are indicated as censored observation at 12 years
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