Phlebotomies of 250-500 mL as frequently as every other day should be performed until a hematocrit of between 40 and 45% is obtained. In older adults and in those with compromised hemodynamic status, only 250-300 mL should be removed each session, with a frequency of not more than twice a week. Once a normal hematocrit is achieved, a blood count should be checked every 4-8 weeks, and phlebotomy should be performed whenever the hematocrit is greater than 45% in men and 42% in women.8

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