Plasma Cell Leukemia

Plasma cell leukemia (PCL) is a rare form of plasma cell dyscrasia characterized by the presence of at least 2.0 X 109/L and more than 20% plasma cells in the peripheral blood differential leukocyte count. PCL may be classified as primary, when it presents in the leukemic phase, or secondary, when there is leukemic transformation of a previously recognized multiple myeloma. Approximately 60% of patients with PCL have the primary type.27 28 Secondary PCL occurs in about 1% of patients with multiple myeloma.

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