Preface

The clinical aspects of hematologic malignancies have changed dramatically over the past decade. The development of targeted therapies, based on years of advanced understanding of basic scientific mechanisms of disease, has led to their widespread use and ultimately to the first decrease in cancer-related mortality not attributable to screening programs. The impact of these advances will be fully felt over the next two decades, when the population of older adults in the United States is expected to double, and continued evolution of intensive therapy and supportive measures will make approaches such as bone marrow transplantation available to more patients than ever before.

Resources available to clinical oncologists or hema-tologists who treat patients with hematologic malignancies are limited. With this in mind, we planned a textbook devoted solely to this topic. Recognizing, also, that oncologists and hematologists are busier than ever and require accessible information about specific topics, we asked our authors to write focused chapters that address different aspects of a disease, and that would be useful to both general and disease-specific practicing oncologists and hematologists, physicians-in-training, researchers, and nurses. We are proud of the end-product.

Sections of Clinical Malignant Hematology are divided by disease, and each disease is further divided into specialty areas where applicable. These areas include epidemiology, risk factors, and classification; molecular biology, pathology, and cytogenetics; clinical features and making the diagnosis; treatment approach to all disease subtypes; and treatment of relapsed or refractory disease, including new frontiers in therapy. In addition, we have included chapters about specialty topics within hematologic malignancies, both within disease sections and in the last part of the book. These topics range from disease-specific indications for bone marrow transplantation and management of infections to treatment of the pregnant patient with a hematologic malignancy and fertility issues in this patient population.

Chapter authors are world experts in their fields. We asked them to use evidence-based findings in the presentation of their material but not at the expense of offering practical information about managing these complicated and often very sick patients. We are grateful to our authors for rising to this challenge and helping us to produce the first definitive textbook on hematologic malignancies. We welcome your feedback about the content and about any areas you would want to see expanded for future editions, particularly as some material may not keep pace with the rapid change in therapy. We ask you to e-mail comments to our editor at McGraw-Hill, Robert Pancotti: [email protected].

Mikkael A. Sekeres, MD, MS Matt E. Kalaycio, MD Brian J. Bolwell, MD February, 2007

Pregnancy Guide

Pregnancy Guide

A Beginner's Guide to Healthy Pregnancy. If you suspect, or know, that you are pregnant, we ho pe you have already visited your doctor. Presuming that you have confirmed your suspicions and that this is your first child, or that you wish to take better care of yourself d uring pregnancy than you did during your other pregnancies; you have come to the right place.

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