Primary Induction Failure

Several studies have shown that some patients who fail primary induction therapy can still be cured if treated with allogeneic transplantation. For example, the European Bone Marrow Transplant Group reported long-term survival in 20% of such patients treated with matched sibling transplantation.36 These results emphasize the importance of HLA-typing patients and family members at the time of diagnosis so that valuable time will not be lost should induction therapy fail. This is particularly important if the patient does not have a matched sibling and an alternative source of stem cells, such as a matched unrelated donor or unrelated cord blood, must be identified.

0 0

Post a comment