Clinical aggressiveness is often confused with prognosis but does not have the same meaning. For example, ALCL, a high-grade neoplasm, is clinically aggressive but has a good prognosis since it responds excellently to therapy.18 A variety of prognostic factors within each disease influence the clinical outcome. One of these is histological grade, but clinical features are also important. The more important of these have been collected together to form the International Prognostic Index (IPI),19 the measurement of which is a powerful predictor of clinical outcome in any given patient.

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