Prognostic Factors

Tumor-associated prognostic features are related to the morphologic pattern—the mantle zone variant tends to behave more indolently while the blastoid variant is aggressive.40 Clinical prognostic factors for MCL include poor performance status, anemia, splenomegaly, and advanced age.23 Mutations in p53, abnormalities in the CDK inhibitors p16-p21, a high Ki67 staining index, unmutated IgVH gene, elevated p2M, and overexpression of topo I.I a are all usually associated with aggressive behavior.

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