Racial Difference In Mm Incidence

While many cancers (namely, those of the esophagus, cervix, stomach, pancreas, larynx, and prostate) have a higher rate among blacks than whites, within the hematopoietic system, MM is the only malignancy with a higher incidence among blacks. Asians have the lowest incidence rate of MM (less than

1/100,000). Table 80.2 and Figure 80.1 describe MM incidence in the US white and black males and females categorized by age at diagnosis.3 This difference in MM incidence is also reported in Jamaica and South Africa, where blacks are reported to have a higher incidence than that reported for US blacks.1314 There is no definitive data to suggest that the higher incidence of MM in blacks is associated with biologically different disease. In some studies, black MM patients were, on average, 10 years younger than white patients and had higher incidence of fractures, paraplegia, and infections.15

Many explanations for the difference in incidence of MM between blacks and white have been proposed. Socioeconomic data showed that MM risk was significantly higher in the lowest categories of occupation, education, and income. In a population-based case-control study including 573 cases (206 blacks and 367 whites), low socioeconomic status was noted for 37% of MM in blacks and 17% in whites, and accounted for 49% of the excess incidence of MM in blacks.16

Differences in lifestyle between blacks and whites failed to show significant risks associated with cigarettes

Table 80.2 Multiple myeloma incidence in the United States: white and black males and females categorized by age at diagnosis

Age category at diagnosis 30-39 40-49 50-59 60-69 70+

Table 80.2 Multiple myeloma incidence in the United States: white and black males and females categorized by age at diagnosis

Age category at diagnosis 30-39 40-49 50-59 60-69 70+

White male

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