Radiation Therapy

In addition to the use of prophylactic cranial radiation for prevention of CNS disease, some protocols have included mediastinal radiation for patients who present with isolated or bulky mediastinal disease. The benefit of this approach is unknown. A report from MD Anderson Cancer Center described 47 patients over an 18-year period who received mediastinal radiation as a component of their initial induction therapy.33 The use of mediastinal irradiation was associated with a lower incidence of mediastinal relapse, but had no effect on failure-free or overall survival. The 5-year overall and progression-free survival rates of 66 and 64% reported in this series are comparable to many other regimens that do not include mediastinal radiation.

0 0

Post a comment