Recommended Treatment Approach For Early Stage Mycosis Fungoides

Nonrandomized clinical trials have not suggested that any one skin-directed therapy is preferable. Treatment choice should be made with the patient's preference and practitioner's skill in mind. Our philosophy regarding the management of patients is to maximize benefits while minimizing side effects. Therefore, we advocate the use of topical monotherapy. If patients fail to respond, we switch to a different topical therapy. Our first-line treatment for early stage patients is PUVA or NB-UVB therapy. However, in cases of refractory early stages we consider combination therapy such as PUVA or NB-UVB with low-dose systemic bexarotene or INF-a.

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