Recommended Treatment Approach For Primary Cutaneous Bcell Lymphoma

The clinical course and prognosis of CBCL is excellent and significantly differs from systemic lymphomas. Our approach to treatment strategies depends on the number and localization of lesions and the patient's age and health condition. The tox-icity of treatment should not outweigh the cosmetic and functional disability of the disease. We prefer initial observation for patients with unifocal or mul-tifocal lesions. If cosmetic consequences are a concern, we use local therapies such as radiation, intrale-sional steroid injection, and surgery or rituximab. We reserve systemic doxorubicin-based chemotherapy with or without rituximab for recurrent multile-sional or disseminated cutaneous or extracutaneous tumors or LBCL of the leg.

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