References

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2. Kuppers R, Rajewsky K, Zhao M, et al.: Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histologi-cal sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA 91:10962-10966, 1994.

3. Kanzler H, Kuppers R, Hansmann ML, Rajewsky K: Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 184:1495-1505, 1996.

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5. Marafioti T, Hummel M, Foss HD, et al.: Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 95:1443-1450, 2000.

6. Marafioti T, Hummel M, Anagnostopoulos I, Foss HD, Huhn D, Stein H: Classical Hodgkin's disease and follicu-lar lymphoma originating from the same germinal center B cell. J Clin Oncol 17:3804-3809, 1999.

7. Laumen H, Nielsen PJ, Wirth T: The BOB.1 / OBF.1 co-activator is essential for octamer-dependent transcription in B cells. Eur J Immunol 30:458-469, 2000.

8. Re D, Muschen M, Ahmadi T, et al.: Oct-2 and Bob-1 deficiency in Hodgkin and Reed Sternberg cells. Cancer Res 61:2080-2084, 2001.

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are positive for epithelial membrane antigen (EMA).19,40 Another helpful phenotypic feature of nLPHL is that the neoplastic cells are typically ringed by small T-cells that often coexpress CD57.43,44 The presence of nodules of CD21 positive follicular dendritic cells also assists in the differential diagnosis with TCRLBL.41

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