1. Hodgkin T: On some morbid appearances of the absorbent glands and spleen. Med Chir Trans 17:69-97, 1832.

2. Kuppers R, Rajewsky K, Zhao M, et al.: Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histologi-cal sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA 91:10962-10966, 1994.

3. Kanzler H, Kuppers R, Hansmann ML, Rajewsky K: Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 184:1495-1505, 1996.

4. Hummel M, Ziemann K, Lammert H, Pileri S, Sabattini E, Stein H: Hodgkin's disease with monoclonal and poly-clonal populations of Reed-Sternberg cells. N Engl J Med 333:901-906, 1995.

5. Marafioti T, Hummel M, Foss HD, et al.: Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 95:1443-1450, 2000.

6. Marafioti T, Hummel M, Anagnostopoulos I, Foss HD, Huhn D, Stein H: Classical Hodgkin's disease and follicu-lar lymphoma originating from the same germinal center B cell. J Clin Oncol 17:3804-3809, 1999.

7. Laumen H, Nielsen PJ, Wirth T: The BOB.1 / OBF.1 co-activator is essential for octamer-dependent transcription in B cells. Eur J Immunol 30:458-469, 2000.

8. Re D, Muschen M, Ahmadi T, et al.: Oct-2 and Bob-1 deficiency in Hodgkin and Reed Sternberg cells. Cancer Res 61:2080-2084, 2001.

9. Stein H, Marafioti T, Foss HD, et al.: Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Blood 97:496-501, 2001.

10. Torlakovic E, Tierens A, Dang HD, Delabie J: The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease. Am J Pathol 159:1807-1814, 2001.

are positive for epithelial membrane antigen (EMA).19,40 Another helpful phenotypic feature of nLPHL is that the neoplastic cells are typically ringed by small T-cells that often coexpress CD57.43,44 The presence of nodules of CD21 positive follicular dendritic cells also assists in the differential diagnosis with TCRLBL.41

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