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wide consensus document on the classification of lymphoma/leukemia.

Classically, three immunophenotypic variants are described. All hairy cells express the pan-B-cell antigens CD19 and CD20. They are negative for CD5, CD10, and CD23. The classic variant coexpresses CD11c, CD25, and CD103. The variant group accounts for 10% of hairy cell cases and expresses CD11c, but not CD25. Expression of CD103 is variable. The survival of the variant form seems to be inferior to the classic type, most likely due to chemoresistance. The Japanese variant is CD11c positive, and occasionally CD103 positive, but CD25 negative.29-32

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