References

1. The Non-Hodgkin's Lymphoma Pathologic Classification Project: National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas. Cancer 449:2112-2135, 1982.

2. Harris NL, Jaffe ES, Stein H, et al.: A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361-1392, 1994.

3. Harris NL, Jaffe ES, Diebold J, et al.: World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting—Airlie House, Virginia. J Clin Oncol 17:3835-3849, 1999.

4. Jaffe ES, Harris NL, Stein H, et al.: Tumours of haematopoietic and lymphoid tissues. In: World Health Organization Classification of Tumours: Pathology & Genetics. Lyon, France: IARC Press, 2001.

5. Ott G, Katzenberger T, Lohr A, et al.: Cytomorphologic, immunohistochemical, and cytogenetic profiles of fol-licular lymphoma: 2 types of follicular lymphoma grade 3. Blood 99:3806-3812, 2002.

6. Chau I, Jones R, Cunningham D, et al.: Outcome of fol-licular lymphoma grade 3: is anthracycline necessary as front-line therapy? Br J Cancer 89:36-42, 2003.

7. Hans CP, Weisenburger DD, Vose JM, et al.: A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival. Blood 101:2363-2367, 2003.

8. Hsi ED, Mirza I, Lozanski G, et al.: A clinicopathologic evaluation of follicular lymphoma grade 3A versus grade 3B reveals no survival differences. Arch Pathol Lab Med 128:863-868, 2004.

9. Shipp MA, Harrington DP, Anderson JR, et al.: Development of a predictive model for aggressive lymphoma: the International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med 329:987-994, 1993.

10. Solal-Celigny P, Roy P, Colombat P, et al.: Follicular lymphoma international prognostic index. Blood 104:1258-1265, 2004.

11. Cheson BD, Horning SJ, Coiffier B, et al.: Report of an International Workshop to standardize response criteria for non-Hodgkin's lymphomas. J Clin Oncol 17: 1244-1253, 1999.

12. Löpez-Guillermo A, Montserrat E, Bosch F, et al.: Applicability of the International Prognostic Index for aggressive lymphomas in patients with low-grade lymphoma. J Clin Oncol 12:1343-1348, 1994.

13. Hermans J, Krol ADG, van Groningen K, et al.: International prognostic index for aggressive non-Hodgkin's lymphoma is valid for all malignancy grades. Blood 86:1460-1463, 1995.

14. Mac Manus M, Hoppe RT: Is radiotherapy curative for stage I and II low-grade follicular lymphoma? Results of a long-term follow-up study of patients treated at Stanford University. J Clin Oncol 14:1282-1290, 1996.

15. Advani R, Rosenberg SA, Horning SJ: Stage I and II fol-licular non-Hodgkin's lymphoma: long-term follow-up of no initial therapy. J Clin Oncol 22:1454-1459, 2004.

16. Horning SJ, Rosenberg SA: The natural history of initially untreated low-grade non-Hodgkin's lymphoma. N Engl J Med 311:1471-1475, 1984.

17. Dana BW, Dahlberg S, Nathwani BN, et al.: Long-term follow-up of patients with low-grade malignant lymphomas treated with doxorubicin-based chemotherapy or chemoimmunotherapy. J Clin Oncol 11:644-651, 1993.

18. Young RC, Longo DL, Glatstein E, et al.: The treatment of indolent lymphomas: watchful waiting v aggressive combined modality treatment. Semin Hematol 25: 11-16, 1988.

19. Brice P, Bastion Y, Lepage E, et al.: Comparison of low-tumor-burden follicular lymphomas between an initial no-treatment policy, prednimustine, or interferon alfa: a randomized study from the Group D'Etude des Lymphomes Folliculares. J Clin Oncol 15:1110-1117, 1997.

20. Kimby E, Björkholm M, Gahrton G, et al.: Chlorambucil/prednisone vs. CHOP in symptomatic low-grade non-Hodgkin's lymphomas: a randomized trial from the Lymphoma Group of Central Sweden. Ann Oncol 5:567-571, 1994.

21. Hochster HS, Kim K, Green MD, et al.: Activity of flu-darabine in previously treated non-Hodgkin's low-grade lymphoma: results of an Eastern Cooperative Oncology Group study. J Clin Oncol 10:28-32, 1992.

22. Redman JR, Cabanillas F, Velasquez WS, et al.: Phase II trial of fludarabine phosphate in lymphoma: an effective new agent in low-grade lymphoma. J Clin Oncol 10:790-794, 1992.

23. Zinzani PL, Lauria F, Rondelli D, et al.: Fludarabine: an active agent in the treatment of previously-treated and untreated low-grade non-Hodgkin's lymphoma. Ann Oncol 4:575-578, 1993.

24. Pigaditou A, Rohatiner AZS, Whelan JS, et al.: Fludarabine in low-grade lymphoma. Semin Oncol 20:24-27, 1993.

25. Hiddemann W, Unterhalt M, Pott C, et al.: Fludarabine single-agent therapy for relapsed low-grade non-Hodgkin's lymphomas: a phase II study of the German Low-grade Non-Hodgkin's Lymphoma Study Group. Semin Oncol 20:28-31, 1993.

26. Solal-Celigny P, Brice P, Brousse N, et al.: Phase II trial of fludarabine monophosphate as first-line treatment in patients with advanced follicular lymphoma: a multicenter study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 14:514-519, 1996.

27. Flinn IW, Byrd JC, Morrison C, et al.: Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies. Blood 96:71-75, 2000.

28. Velasquez WS, Lew D, Grogan TM, et al.: Combination of fludarabine and mitoxantrone in untreated stages III and IV low-grade lymphoma: S9501. J Clin Oncol 21:1996-2003, 2003.

29. Zinzani PL, Pulsoni A, Perrotti A, et al.: Fludarabine plus mitoxantrone with and without rituximab versus CHOP with and without rituximab as front-line treatment for patients with follicular lymphoma. J Clin Oncol 22:2654-2661, 2004.

30. Merigan TC, Sikora K, Breeden JH, et al.: Preliminary observations on the effect of human leukocyte interferon in non-Hodgkin's lymphoma. N Engl J Med 299:1449-1553, 1978.

31. Foon KA, Sherwin SA, Abrams PG, et al.: Treatment of advanced non-Hodgkin's lymphoma with recombinant leukocyte A interferon. N Engl J Med 311:1148-1152, 1984.

32. O'Connell MJ, Colgan JP, Oken MM, et al.: Clinical trial of recombinant leukocyte A interferon as initial therapy for favorable histology non-Hodgkin's lymphomas and chronic lymphocytic leukemia. An Eastern Cooperative Oncology Group pilot study. J Clin Oncol 4:128-136, 1986.

33. Solal-Celigny P, Lepage E, Brousse N, et al.: Recombinant interferon alfa-2b combined with a regimen containing doxorubicin in patients with advanced follicular lymphoma. N Engl J Med 329:1608-1614, 1993.

34. Solal-Celigny P, Lepage E, Brousse N, et al.: A doxoru-bicin-containing regimen with or without interferon alpha-2b for advanced follicular lymphomas: final analysis of survival and toxicity in the GELF 86 trial. J Clin Oncol 16:2332-2338, 1998.

35. Smalley RV, Andersen JW, Hawkins MJ, et al.: Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma. N Engl J Med 327:1336-1341, 1992.

36. Aviles A, Duque G, Talavera A, et al.: Interferon alpha 2b as maintenance therapy in low grade malignant lymphoma improves duration of remission and survival. Leuk Lymphoma 20:495-499, 1996.

37. Unterhalt M, Hermann R, Koch P, et al.: Long term interferon alpha maintenance prolongs remission duration in advanced low grade lymphomas and is related to the efficacy of initial cytoreductive therapy. Blood 88:453a, 1996. Abstract 1801.

38. Hagenbeek A, Carde P, Meerwaldt JH, et al.: Maintenance of remission with human recombinant interferon alfa-2a in patients with stages III and IV low-grade malignant non-Hodgkin's lymphoma. J Clin Oncol 16:41-47, 1998.

39. Fisher RI, Dana BW, LeBlanc M, et al.: Alpha-interferon consolidation following intensive chemotherapy does not prolong the failure-free survival of patients with low grade non-Hodgkin's lymphoma: results of SWOG-8809, a randomized phase III study. J Clin Oncol 18:2010-2016, 2000.

40. Chisesi T, Congiu M, Contu A, et al.: Randomized study of chlorambucil (CB) compared to interferon (alfa-2b) in low-grade non-Hodgkin's lymphoma: an interim report of a randomized study. Eur J Cancer 27:S31-S33, 1991.

41. Price CGA, Rohatiner AZS, Steward W, et al.: Interferon alfa-2b in addition to chlorambucil in the treatment of follicular lymphoma: preliminary results of a randomized trial in progress. Eur J Cancer 27:S34-S36, 1991.

42. Peterson BA, Petroni G, Oken MM, et al.: Cyclophosphamide versus cyclophosphamide plus interferon alfa-2b in follicular low grade lymphomas: a preliminary report of an intergroup trial (CALGB 8691 and EST 7486). Proc Am Soc Clin Oncol 12:366, 1993. Abstract 1240.

43. Arranz R, Garcia-Alfonso P, Sobrino P, et al.: Role of interferon alfa-2b in the induction and maintenance treatment of low-grade non-Hodgkin's lymphoma: results from a prospective, multicenter trial with double randomization. J Clin Oncol 16:1538-1546, 1998.

44. Rohatiner AZS, Gregory W, Peterson B, et al.: A metaanalysis (MA) of randomised trials evaluating the role of interferon (IFN) as treatment for follicular lymphoma (FL). Proc Am Soc Clin Oncol 17:4a, 1998. Abstract 11.

45. McLaughlin P, Grillo-Lopez AJ, Link BK, et al.: Rituximab chimeric anti-CD20 monoclonal antibody therapy of relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol 16:2825-2833, 1998.

46. Piro LD, White CA, Grillo-Lopez AJ, et al.: Extended rit-uximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma. Ann Oncol 10:655-661, 1999.

47. O'Brien SM, Kantarjian H, Thomas DA, et al.: Rituximab dose-escalation trial in chronic lymphocytic leukemia. J Clin Oncol 19:2165-2170, 2001.

48. Byrd JC, Murphy T, Howard RS, et al.: Rituximab using a thrice weekly dosing schedule in B-cell chronic lym-phocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 19:2153-2164, 2001.

49. Colombat P, Salles G, Brousse N, et al.: Rituximab (anti-CD20 monoclonal antibody) as single first-line therapy for patents with follicular lymphoma with a low tumor burden: clinical and molecular evaluation. Blood 97: 101-106, 2001.

50. Hainsworth JD, Lichty S, Burris HA III, et al.: Rituximab as first-line and maintenance therapy for patients with indolent non-Hodgkin's lymphoma. J Clin Oncol 20: 4261-4267, 2002.

51. Demidem A, Lam T, ALas S, et al.: Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B cell lymphoma cell line to cell killing by cytotoxic drugs. Cancer Biother Radiopharm 12:177-186, 1997.

52. Johnson TA, Press OW: Synergistic cytotoxicity of iodine-131-anti-CD20 antibodies and chemotherapy for treatment of B-cell lymphomas. Int J Cancer 85: 104-112, 2000.

53. Czuczman MS, Grillo-Lopez AJ, White CA, et al.: Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy. J Clin Oncol 17:268-276, 1999.

54. Czuczman M, Grillo-Lopez AJ, LoBuglio AF, et al.: Patients with low-grade NHL treated with rituximab + CHOP experience prolonged clinical and molecular remission. Blood 102: Abstract 1493, 2003.

55. Hiddemann W, Dreyling M, Forstpointner R, et al.: Combined immuno-chemotherapy (R-CHOP) significantly improves time to treatment failure in first line therapy of follicular lymphoma—results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). Blood 102: Abstract 352, 2003.

56. Marcus R, Imrie K, Belch A, et al.: An international multi-centre, randomized, open-label phase III trial comparing rituximab added to CVP chemotherapy to CVP chemotherapy alone in untreated stage III/IV fol-licular non-Hodgkin's lymphoma. Blood 102: Abstract 87, 2003.

57. Czuczman MS, Fallon A, Mohr A, et al.: Phase II study of rituximab plus fludarabine in patients (pts) with low-grade follicular lymphoma (LGL): final report. Blood 98:601a, 2001. Abstract 2518.

58. Martinelli G, Laszlo D, Mancuso P, et al.: Rituximab plus chlorambucil in low-grade non Hodgkin's lymphomas (NHL): clinical results of a phase II study. Blood 100:777a, 2002. Abstract 3073.

59. Sacchi S, Tucci A, Merli F, et al.: Phase II study with flu-darabine and cyclophosphamide plus rituximab (FC+R) in relapsed follicular lymphoma patients. Blood 100: 572a, 2002. Abstract 2246.

60. Gregory SA, Venugopal P, Adler S, et al.: Combined flu-darabine, mitoxantrone and rituximab achieves a high response rate as initial treatment for advanced low grade non-Hodgkin's lymphoma (LGNHL). Blood 100:362a, 2002. Abstract 1401.

61. Vitolo U, Boccomini C, Ladetto M, et al.: High clinical and molecular response rate in elderly patients with advanced stage follicular lymphoma treated at diagnosis with a brief chemo-immunotheraepy FND + rituximab. Blood 100:359a, 2002. Abstract 1392.

62. Zinzani PL: A multicenter randomized trial of fludara-bine and mitoxantrone (FM) plus rituximab versus CHOP plus rituximab as first-line treatment in patients with follicular lymphoma. Blood 100:93a, 2002. Abstract 344.

63. Rummel MJ, Kim SZ, Chow KU, et al.: Bendamustine and rituximab act synergistically in vitro and are effective in the treatment of relapsed or refractory indolent and mantle cell lymphomas. Blood 102:104a, 2003. Abstract 353.

64. Ghielmini M, Schmitz SF, Cogliatti SB, et al.: Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with weekly X 4 schedule. Blood 103:4416-4423, 2004.

65. Hochster HS, Weller E, Ryan T, et al.: Results of E1496: A phase III trial of CVP with or without maintenance rituximab in advanced indolent lymphoma (NHL). Proc Am Soc Clin Oncol 22:558s, 2004. Abstract 6502.

66. Davis TA, Grillo-Lopez AJ, White CA, et al.: Rituximab anti-CD20 monoclonal antibody therapy in non-Hodgkin's lymphoma: safety and efficacy of retreat-ment. J Clin Oncol 18:3135-3143, 2000.

67. Hainsworth JD, Litchy S, Greco FA: Scheduled ritux-imab maintenance therapy versus rituximab retreat-ment at progression in patients with indolent non-Hodgkin's lymphoma (NHL) responding to single-agent rituximab: a randomized trial of the Minnie Pearl Cancer Research Network. Blood 102: Abstract 231, 2003.

67a. Van Oers MHJ, Van Glabbeke M, Teodorovic I, et al.: Chimeric anti-CD20 monoclonal antibody (Rituximab; Mabthera) in remission induction and maintenance treatment of relapsed/resistant follicular non-Hodgkin's lymphoma. Final analysis of a phase III randomized intergroup clinical trial. Blood 106(Part 1): 107a (abstract 353), 2005.

68. Weng WK, Levy R: Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 21:3940-3947, 2003.

69. Bohen SP, Troyanskaya OG, Alter O, et al.: Variation in gene expression patterns in follicular lymphoma and response to rituximab. Proc Natl Acad Sci USA 100: 1926-1930, 2003.

70. Mounier N, Briere J, Gisselbrecht C, et al.: Rituximab plus CHOP (R-CHOP) overcomes bcl-2-associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL). Blood 101:4279-4284, 2003.

71. Keating MJ, Flinn I, Jain V, et al.: Therapeutic role of alemtuzumab (CAMPATH-1H) in patients who have failed fludarabine: results of a large international study. Blood 99:3554-3561, 2002.

72. Lundin J, Österborg A, Brittinger G, et al.: CAMPATH-1H monoclonal antibody therapy for previously treated low-grade non-Hodgkin's lymphomas: a phase II multicenter study. J Clin Oncol 16:3257-3263, 1998.

73. Leonard JP, Coleman M, Ketas JC, et al.: Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma. J Clin Oncol 21: 3051-3059, 2003.

74. Emmanouilides C, Leonard J, Schuster SJ, et al.: Multicenter, phase 2 study of combination antibody therapy with epratuzumab plus rituximab in recurring low-grade NHL. Blood 102: Abstract 233, 2003.

75. Czuczman M, Witzig TE, Vose JM, et al.: Results of a phase I/II multicenter trial of galiximab (IDEC-114, anti-CD80 antibody) therapy for relapsed or refractory follicular lymphoma. Blood 102:647-648a, 2003. Abstract 2393.

76. Gordon LI, Moore JO, Cheson BD, et al.: Phase I results from a multicenter trial of galiximab (anti-CD80 antibody, IDEC-114) in combination with rituximab for the treatment of follicular lymphoma. Blood 102:307b, 2003. Abstract 4951.

77. Link BK, Wang H, Byrd JC, et al.: Phase I trial of humanized 1D10 (Hu1D10) monoclonal antibody targeting class II molecules in patients with relapsed lymphoma. Proc Am Soc Clin Oncol 19:24a, 2000. Abstract 86.

78. Link BK, Kahl B, Czuczman M, et al.: A phase II study of Remitogen™ (Hu1D10), a humanized monoclonal antibody in patients with relapsed or refractory follicu-lar, small lymphocytic, or marginal zone/MALT B-cell lymphomas. Blood 98:606a, 2001. Abstract 2540.

79. Stein R, Qu Z, Chen S, et al.: Characterization of a new humanized anti-CD20 monoclonal antibody, IMMU-106, and its use in combination with the humanized anti-CD22 antibody, epratuzumab, for the therapy of non-Hodgkin's lymphoma. Clin Cancer Res 10: 2868-2878, 2004.

80. Cheson BD: Radioimmunotherapy of non-Hodgkin's lymphomas. Blood 101:391-398, 2003.

81. Wiseman GA, Gordon LI, Multani PS, et al.: Ibritumomab tiuxetan radioimmunotherapy for patients with relapsed or refractory non-Hodgkin's lymphoma and mild thrombocytopenia: a phase II multicenter trial. Blood 99:4336-4342, 2002.

82. Witzig TE, White CA, Wiseman GA, et al.: Phase I/II trial of IDEC-Y2B8 radioimmunotherapy for treatment of relapsed or refractory CD20(+) B-cell non-Hodgkin's lymphoma. J Clin Oncol 17:3793-3803, 1999.

83. Witzig TE, Flinn IW, Gordon LI, et al.: Treatment with ibritumomab tiuxetan radioimmunotherapy in patients with rituximab-refractory follicular non-Hodgkin's lymphoma. J Clin Oncol 20:3262-3269, 2002.

84. Witzig TE, Gordon LI, Cabanillas F, et al.: Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma. J Clin Oncol 20:2453-2463, 2002.

85. Gordon LI, Molina A, Witzig T, et al.: Durable responses after ibritumomab tiuxetan radioimmunotherapy for CD20+ B-cell lymphoma: long-term follow-up of a phase 1/2 study. Blood 103:4429-4431, 2004.

86. Kaminski MS, Zelenetz AD, Press OW, et al.: Pivotal study of Bexxar (Iodine I-131 tositumomab) for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphomas. J Clin Oncol 19:3918-3928, 2001.

87. Kaminski MS, Tuck M, Regan D, et al.: High response rate and durable remissions in patients with previously untreated, advanced-stage, follicular lymphoma treated with tositumomab and iodine I-131 tositumomab (Bexxar©). Blood 100:356a, 2002. Abstract 1381.

88. Press OW, Unger JM, Braziel RM, et al.: A phase 2 trial of CHOP chemotherapy followed by tositumomab/iodine

I 131 tositumomab for previously untreated follicular non-Hodgkin's lymphoma: Southwest Oncology Group protocol S9911. Blood 102:1606-1612, 2003.

89. Gopal AK, Gooley TA, Maloney DG, et al.: High-dose radioimmunotherapy versus conventional high-dose therapy and autologous stem cell transplantation for relapsed follicular non-Hodgkin lymphoma: a multivariable cohort analysis. Blood 102:2351-2357, 2003.

90. Bennett JM, Kaminski MS, Knox SJ, et al.: Assessment of treatment-related myelodysplastic syndromes (tMDS) and acute myeloid leukemia (tAML) in patients with low-grade non-Hodgkin's lymphoma (LG-NHL) treated with tositumomab and iodine-131 tositumomab (the Bexxar therapeutic regimen). Blood 102: Abstract 91, 2003.

91. Witzig TE, White CA, Gordon LI, et al.: Safety of yttrium-90 ibritumomab tiuxetan radioimmunotherapy for relapsed low-grade, follicular, or transformed non-Hodgkin's lymphoma. J Clin Oncol 21:1263-1270, 2003.

92. Kaminski M, Bahm V, Estes J, et al.: Tolerance of treatment subsequent to frontline Bexxar™ (tositumomab and iodine I131 tositumomab) in patients (Pts) with fol-licular lymphoma. Blood 98:603a, 2001. Abstract 2526.

93. Ansell SM, Ristow KM, Habermann TM, et al.: Subsequent chemotherapy regimens are well tolerated after radioimmunotherapy with 90Yttrium ibritumomab tiuxetan for non-Hodgkin's lymphoma. J Clin Oncol 20:3885-3890, 2002.

94. Waters JS, Webb A, Cunningham D, et al.: Phase I and pharmacokinetic study of bcl-2 antisense oligonu-cleotide therapy in patients with non-Hodgkin's lymphoma. J Clin Oncol 18:1809-1811, 2000.

95. Hsu FJ, Caspar C, Czerwinski D, et al.: Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma—long term results of a clinical trial. Blood 89:3129-3135, 1997.

96. Kath R, Blumenstengel K, Fricke HJ, et al.: Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia. J Cancer Res Clin Oncol 127:48-54, 2001.

97. Schwänen C, Karakas T, Begmann L: Bendamustine in the treatment of low-grade non-Hodgkin's lymphomas. Onkologie 23:318-324, 2000.

98. Weidmann E, Kim SZ, Rost A, et al.: Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin's lymphoma. Ann Oncol 13:1285-1289, 2002.

99. Bremer K: High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's lymphomas. J Cancer Res Clin Oncol 128:603-609, 2002.

100. Richardson PG, Barlogie B, Berenson JR, et al.: A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 348:2609-2617, 2003.

101. Goy A, Younes A, McLaughlin P, et al.: A phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J Clin Oncol 23:667-675, 2005.

102. O'Connor OA, Wright J, Moskowitz C, et al.: Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J Clin Oncol 23:676-684, 2005.

103. Freedman AS, Nadler LM: Which patients with relapsed non-Hodgkin's lymphoma benefit from high-dose therapy and hematopoietic stem-cell transplantation? J Clin Oncol 11:1841-1843, 1993.

104. Freedman AS, Gribben JG, Neuberg D, et al.: High-dose therapy and autologous bone marrow transplantation in patients with follicular lymphoma. Blood 88: 2780-2786, 1996.

105. Rohatiner AZS, Johnson PWM, Price CGA, et al.: Myeloablative therapy with autologous bone marrow transplantation as consolidation therapy for recurrent follicular lymphoma. J Clin Oncol 12:1177-1184, 1994.

106. Freedman AS, Neuberg D, Mauch P, et al.: Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma. Blood 94:3325-3333, 1999.

107. Schouten HC, Qian W, Kvaloy S, et al.: High-dose therapy improves progression-free survival and survival in relapsed follicular non-Hodgkin's lymphoma: results from the randomized European CUP trial. J Clin Oncol 21:3918-3927, 2003

108. Darrington DL, Vose JM, Anderson JR, et al.: Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies. J Clin Oncol 12:2527-2534, 1994.

109. Miller JS, Arthur DC, Litz CE, et al.: Myelodysplastic syndrome after autologous bone marrow transplantation: an additional late complication of curative cancer therapy. Blood 83:3780-3788, 1994.

110. Stone RM, Neuberg D, Soiffer R, et al.: Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol 12:2535-2542, 1994.

111. Friedberg JW, Neuberg D, Stone RM, et al.: Outcome in patients with myelodysplastic syndrome after autolo-gous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol 17:3128-2135, 1999.

112. van Besien KW, Khouri IF, Giralt S, et al.: Allogeneic bone marrow transplantation for refractory and recurrent low-grade lymphoma: the case for aggressive management. J Clin Oncol 13:1096-1102, 1995.

113. van Besien K, Sobocinski KA, Rowlings PA, et al.: Allogeneic bone marrow transplantation for low-grade lymphoma. Blood 92:1832-1836, 1998.

114. Ratanatharathorn V, Uberti J, Karanes C, et al.: Prospective comparative trial of autologous versus allo-geneic bone marrow transplantation in patients with non-Hodgkin's lymphoma. Blood 84:1050-1055, 1994.

115. Haioun C, Lepage E, Gisselbrecht C, et al.: Comparison of autologous bone marrow transplantation with sequential chemotherapy for intermediate-grade and high-grade non-Hodgkin's lymphoma in first complete remission: a study of 464 patients. J Clin Oncol 12: 2543-2551, 1994.

116. Khouri IF, Keating M, Korbling M, et al.: Transplant-lite: induction of graft-versus malignancy using flu-darabine-based nonablative chemotherapy and allo-geneic blood progenitor-cell transplantation as treatment for lymphoid malignancies. J Clin Oncol 16:2817-2824, 1998.

117. Khouri IF, Saliba RM, Giralt SA, et al.: Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality. Blood 98:3595-3599, 2001.

118. Faulkner RD, Craddock C, Byrne JL, et al.: BEAM-alem-tuzumab reduced-intensity allogeneic stem cell transplantation for lymphoproliferative diseases: GVHD, toxicity and survival in 65 patients. Blood 103:428-434, 2004.

119. Hubbard SM, Chabner B, DeVita VT Jr, et al.: Histologic progression in non-Hodgkin's lymphoma. Blood 59: 258-264, 1982.

120. Yuen AR, Kamel OW, Halpern J, et al.: Long-term survival after histologic transformation of low-grade follic-ular lymphoma. J Clin Oncol 13:1726-1733, 1995.

121. Schouten HC, Bierman PJ, Vaughn WP, et al.: Autologous bone marrow transplantation in follicular non-Hodgkin's lymphoma before and after histologic transformation. Blood 74:2579-2584, 1989.

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