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or only weakly positive.34 74 Both HCL and SMZL cells are of B-cell lineage and are CD19 and CD20 positive, with Ig light-chain restriction, as well as CD10 and CD5 negative. However, the SMZL cells are usually CD103 and CD123 negative.54 75-77 The bone marrow infiltrates are sharply demarcated from the surrounding normal tissue, and intrasinusoidal infiltration is often prominent, Figures 30.6(a) and (b). In addition, sections of spleen show predominantly white pulp involvement resembling that of low-grade lymphoma.74

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